Temple College is located in Temple, (Bell County) Texas, a vibrant, progressive city of approximately 58,000 in Central Texas. Temple is recognized as a medical, education and research center. Within its boundaries are Scott & White Hospital and Clinics, King's Daughters Hospital and Clinic, Central Texas Veterans' Health Care System, Texas A&M Health Science Center College of Medicine, and USDA/Texas A&M University Blackland Research Center. The city also has a broad industrial base and is home to several national and international manufacturing and distribution companies. The Temple Health and Bioscience District was recently established to support economic development in bioscience. Temple College also is part of the newly established Temple Medical Education District.

Temple is conveniently located on the edge of the Texas Hill Country, just 60 miles north of Austin, and within easy driving distance to major metropolitan areas. Residents enjoy an excellent quality of life with good schools and churches, as well as many options for shopping, dining, entertainment and recreation. Excellent educational services are provided by public and private schools. Temple has numerous community parks and recreational areas, golf courses, and two large lakes within 15 miles of the city. Residents enjoy strong cultural arts programs including a civic theatre, professional symphony orchestra, cultural arts center and museums.