Name

haloperidol (Haldol®)

Class

Antipsychotic

Butyrophenone

Description/Mechanism

Potent, long-acting butyrophenone derivative with pharmacologic actions similar to those of phenothiazines but with higher incidence of extrapyramidal effects and less hypotensive and relatively low sedative activity. Exerts strong antiemetic effect and impairs central thermoregulation. Produces weak central anticholinergic effects and transient orthostatic hypotension.

Onset

IV: 10-20 minutes

IM: 30-60 minutes

Duration

12-24 hours

Indications

Acute psychotic episode

Contraindications

CNS depression

Coma

Hypersensitivity

Pregnancy

Adverse Reactions

Dose-related

• Pseudoparkinsonism
• Akathisia
• Dystonias

Orthostatic hypotension

Nausea and vomiting

Allergic reactions

Blurred vision

Drug Interactions

Other CNS depressants may potentiate effects.

May inhibit vasoconstrictor effects of epinephrine

Supplied

5mg/ml ampule

Dose/Administration

Adult

2-5 ml IM

Pediatric

Not recommended in pediatric patients.

Special Consideration

Pregnancy Safety: C