Name

fentanyl (Sublimaze®)

Class

Narcotic analgesic

Description/Mechanism

Synthetic, potent narcotic agonist analgesic with actions similar to morphine but much more potent and less prolonged. Less emetic and vasodilatory effects than with morphine.

Onset

< 1 minute IV

Duration

30 - 60 minutes IV

Indications

analgesia

sedation during RSI

Contraindications

MAO inhibitors

myasthenia gravis

Use with caution in head injuries.

Adverse Reactions

sedation

nausea

respiratory depression

miosis

hypotension

rapid administration may result in chest wall rigidity that will not respond to neuromuscular blockade.

Drug Interactions

Alcohol and other CNS depressants potentiate effects.

MAO inhibitors may precipitate hypertensive crisis.

Supplied

50.0 mcg/ml (2, 5, 10, 20 & 50 ml vials)

Dose/Administration

Adult

IV 1 - 10 mcg/kg

Pediatric

Same as adult

Special Consideration

Pregnancy class C

Incompatible with pentobarbital and thiopental.

Schedule II controlled substance.