aspirin (Bayer®, others)
salicylate, antipyretic, NSAID
NOT an anticoagulant
Powerfully inhibits platelet aggregation by inhibiting thrombonxane A2 production. Major actions appear to be associated primarily with inhibiting the formation of prostaglandins involved in the production of inflammation, pain and fever. Lowers body temperature by indirectly causing centrally mediated peripheral vosodilation and sweating.
~ 15 min
2 - 4 hours
Acute myocardial injury/infarction
Relieve pain of low to moderate intensity.
Inflammatory conditions
Reduce fever
Prevent recurrence of MI and TIA
Hypersensitivity to salicylates
History of GI ulceration
Hemophilia or other bleeding disorders
Pregnancy or children under 2 years
dizziness, confusion, tinnitus, hearing loss, nausea, heartburn, stomach pains
anticoagulants increase risk of bleeding
Varied preparations
PO/PR: 325 mg "baby aspirin" for MI/TIA chew and swallow
contraindicated.
Pregnancy Safety: Category D