amiodarone (Cordarone®)
Antiarrhythmic (Class III)
Prolongs duration of action potential and effective refractory period, also provides noncompetitive a- and b- adrenergic inhibition. Decreases AV conduction velocity and sinus node function.
within minutes with IV administration
days (not firmly established)
VF, unstable VT and SVT refractory to other therapy. Trials underway or recently completed indicated amiodarone is an effective first line medication for VT/VF in cardiac arrest.
None in cardiac arrest with VF or VT. High degree AV blocks, sinus node dysfunction and marked bradycardia.
Hypotension, bradycardia
Enhanced bradycardia and hypotension when given with other b-blockers or calcium channel blockers.
50 mg/ml
IV: 300 mg bolus in cardiac arrest.
IV use of amiodarone is a new intervention based on its successful use in several clinical trials. Must be drawn up slowly to avoid foaming.