anisoylated plasminogen streptokinase activator (APSAC®, Anistreplase®)
fibrinolytic (thrombolytic)
Anisoylated plasminogen streptokinase activator is a complex that converts plasminogen to the proteolytic enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and certain other plasma proteins. Following administration, plasma fibrinogen levels are decreased for 24-36 hours, and thrombin time may remain prolonged for 24 hours.
10-20 minutes
12-24 hours
Acute evolving transmural myocardial infarction.
Active bleeding, recent CVA, intracranial or intraspinal surgery
Uncontrolled hypertension, severe allergy to the product.
Prolonged CPR, trauma, recent surgery (within 2-3 weeks), peptic ulcer disease, other bleeding disorder.
Bleeding
Dysrhythmias (IVR, Sinus Bradycardia, 2nd and 3rd degree AV Block
Allergic reactions
Aspirin and heparin may increase risk of bleeding (both agents may be given concurrently to improve overall efficacy)
Injection: 30 units (1 unit equivelant to 1 mg, which contains 36,000 IU of streptokinase). Store at 5 degrees C.
30 units reconstituted in 5ml sterile water for injection; administer over 5 minutes.
Consideration Pregnancy Safety: Contraindicated.
Gently roll – do not shake- the vial to mix the powder with the liquid.
Medication must be used within 30 minutes following reconsitution.